{"id":8260,"date":"2025-02-26T17:49:14","date_gmt":"2025-02-26T16:49:14","guid":{"rendered":"https:\/\/everydaybetter.nl\/?p=8260"},"modified":"2026-10-02T20:30:33","modified_gmt":"2026-10-02T18:30:33","slug":"nmn-metabolism-and-insulin-sensitivity-a-breakthrough-for-prediabetes-and-aging","status":"publish","type":"post","link":"https:\/\/everydaybetter.nl\/en\/nmn-metabolism-and-insulin-sensitivity-a-breakthrough-for-prediabetes-and-aging\/","title":{"rendered":"NMN, metabolism and insulin sensitivity: A breakthrough for prediabetes and aging?"},"content":{"rendered":"\n

This article discusses a published scientific study. It is not a claim about the effect of Every Day Better NMN Powder specifically, and is not a substitute for medical advice regarding prediabetes. <\/em><\/p>\n\n\n\n

Background: NMN and insulin sensitivity<\/h2>\n\n\n\n

A study published in Science<\/em><\/a> (2021, also available on PubMed<\/a> and summarized by the American NIDDK<\/a>) investigated the effect of NMN supplementation on insulin sensitivity in overweight, prediabetic postmenopausal women. Animal models had previously shown that NAD\u207a biosynthesis becomes disrupted by obesity and aging; NMN is a precursor to NAD\u207a. <\/p>\n\n\n\n

\"Insulin<\/figure>\n\n\n\n

Study design<\/h2>\n\n\n\n

A randomized, placebo-controlled, double-blind 10-week study of 25 postmenopausal women with prediabetes. One group received 250 mg of NMN daily, the other a placebo. Insulin sensitivity was measured via a hyperinsulinemic-euglycemic clamp, with muscle biopsies for molecular research. <\/p>\n\n\n\n

Results: NMN and insulin sensitivity<\/h2>\n\n\n\n
\"Effect<\/figure>\n\n\n\n

The NMN group showed a significant increase in insulin-mediated glucose uptake in the muscles compared to placebo, with changes in insulin signaling (AKT, mTOR) and muscle remodeling.<\/p>\n\n\n\n

What this does and does not mean for insulin sensitivity<\/h2>\n\n\n\n

This is a single study with a small sample size (25 participants) and a short duration (10 weeks), in a specific target group (postmenopausal women with prediabetes) and a specific dosage (250 mg\/day). The researchers themselves emphasize that larger and longer studies are needed. Therefore, this research says nothing definitive about the risk of developing diabetes and is not a basis for stating that NMN supplementation in general\u2014let alone a specific product\u2014treats or prevents prediabetes. <\/p>\n\n\n\n

Important<\/h2>\n\n\n\n

If you have prediabetes or type 2 diabetes, medical supervision is and remains the foundation. Supplements are not a substitute for treatment, diet, or exercise. Always consult with your doctor before using supplements if you have an existing metabolic condition. <\/p>\n\n\n\n

Conclusion: NMN and insulin sensitivity<\/h2>\n\n\n\n

This study is an interesting initial signal from clinical research, not a proven treatment. Further research\u2014with more participants and longer follow-up\u2014is needed before firmer conclusions can be drawn. <\/p>\n\n\n\n

View our NMN products<\/a><\/p>\n\n\n\n

Want to know more? Read how to take NMN powder<\/a> and explore our supplements for energy and focus<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

This article discusses a published scientific study. It is not a claim about the effect of Every Day Better NMN Powder specifically, and is not a substitute for medical advice…<\/p>\n","protected":false},"author":1,"featured_media":17006,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[520,1084,1083,480,473],"tags":[474],"class_list":["post-8260","post","type-post","status-publish","format-standard","has-post-thumbnail","category-nmn-en","category-insulin","category-metabolism","category-nad","category-science","tag-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/everydaybetter.nl\/en\/wp-json\/wp\/v2\/posts\/8260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/everydaybetter.nl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/everydaybetter.nl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/everydaybetter.nl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/everydaybetter.nl\/en\/wp-json\/wp\/v2\/comments?post=8260"}],"version-history":[{"count":0,"href":"https:\/\/everydaybetter.nl\/en\/wp-json\/wp\/v2\/posts\/8260\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/everydaybetter.nl\/en\/wp-json\/wp\/v2\/media\/17006"}],"wp:attachment":[{"href":"https:\/\/everydaybetter.nl\/en\/wp-json\/wp\/v2\/media?parent=8260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/everydaybetter.nl\/en\/wp-json\/wp\/v2\/categories?post=8260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/everydaybetter.nl\/en\/wp-json\/wp\/v2\/tags?post=8260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}