This article discusses a published scientific study. It is not a claim about the effect of Every Day Better NMN Powder specifically, and is not a substitute for medical advice regarding prediabetes.
Background: NMN and insulin sensitivity
A study published in Science (2021, also available on PubMed and summarized by the American NIDDK) investigated the effect of NMN supplementation on insulin sensitivity in overweight, prediabetic postmenopausal women. Animal models had previously shown that NAD⁺ biosynthesis becomes disrupted by obesity and aging; NMN is a precursor to NAD⁺.
Study design
A randomized, placebo-controlled, double-blind 10-week study of 25 postmenopausal women with prediabetes. One group received 250 mg of NMN daily, the other a placebo. Insulin sensitivity was measured via a hyperinsulinemic-euglycemic clamp, with muscle biopsies for molecular research.
Results: NMN and insulin sensitivity
The NMN group showed a significant increase in insulin-mediated glucose uptake in the muscles compared to placebo, with changes in insulin signaling (AKT, mTOR) and muscle remodeling.
What this does and does not mean for insulin sensitivity
This is a single study with a small sample size (25 participants) and a short duration (10 weeks), in a specific target group (postmenopausal women with prediabetes) and a specific dosage (250 mg/day). The researchers themselves emphasize that larger and longer studies are needed. Therefore, this research says nothing definitive about the risk of developing diabetes and is not a basis for stating that NMN supplementation in general—let alone a specific product—treats or prevents prediabetes.
Important
If you have prediabetes or type 2 diabetes, medical supervision is and remains the foundation. Supplements are not a substitute for treatment, diet, or exercise. Always consult with your doctor before using supplements if you have an existing metabolic condition.
Conclusion: NMN and insulin sensitivity
This study is an interesting initial signal from clinical research, not a proven treatment. Further research—with more participants and longer follow-up—is needed before firmer conclusions can be drawn.
Want to know more? Read how to take NMN powder and explore our supplements for energy and focus.
