The science behind NMN, TMG and GlyNAC

Podcasts from Every Day Better about energy, vitality and healthy aging, without miracle cures.

The science behind NMN, TMG and GlyNAC is the podcast from Every Day Better about energy, vitality and healthy aging. Founder Roald Reurink discusses one side of the NAD⁺ story in each episode: from cell biology to product quality, from festival recovery to the latest state of research. No miracle cures and no exaggerated claims — just clear explanations, nuance and honest conclusions about what is and isn’t known yet.

The podcast is intended for everyone researching longevity supplements such as NMN, TMG and GlyNAC: from complete beginners to those who have been involved with NAD⁺ support for some time. Each episode stands on its own, so you can start wherever you like — a good starting point is the most recent episode, in which the three substances are compared side-by-side.

Want to know more about the quality criteria and certification behind Every Day Better’s NMN products? Read the background in our NMN guide and certificates, or view the full range in the shop.

All podcasts

Latest first. Each title opens the episode on Spotify. Most are in Dutch but episode 3 is in English.

What each episode is about

Full summaries per episode — useful if you want to read what an episode is about first, or look up a specific topic.

Ep. 06 — Supplements for healthy aging in 2026Jul 12, 2026

The most recent episode brings NMN, TMG and GlyNAC together: how the three substances relate to each other, when to combine them, and what to look for when purchasing supplements — purity, dosage per capsule, independent tests. Roald emphasizes that supplements are an addition, not the foundation: nutrition, exercise, sleep and stress management remain the fundamentals for healthy aging. A good starting point or summary of previous episodes. See also the certification overview.

Ep. 05 — NMN research 2026: what do we really know?Jun 4, 2026

A critical update: what has research in 2026 yielded about NMN, and what still hasn’t? Topics include safety data, dosage research and why there is still no hard evidence that NMN slows aging in humans — despite promising signals from cell and animal studies. The episode explicitly distinguishes what has been proven from what is still a hypothesis, and warns against exaggerated marketing claims elsewhere in the supplement market.

Ep. 04 — NMN, GlyNAC and TMG: the foundation of energy & longevityENApr 10, 2026

This English-language episode explains, for an international audience, how declining NAD⁺ relates to ageing, how GlyNAC supports glutathione production, and how TMG supports methylation. Roald Reurink walks through the fundamentals behind all three supplements in one concise overview — a useful starting point for English-speaking listeners new to the topic.

Ep. 03 — NMN & ADE 2025: biohacking during the Amsterdam Dance EventOct 16, 2025

Around the Amsterdam Dance Event, Roald discusses how NMN is used by people who want to support their bodies during physically and mentally demanding periods — such as festivals: focus, recovery and energy management are central. The episode places this within the broader biohacking culture and explains the underlying mechanism (cellular energy via NAD⁺) without overstating the science, with practical tips on sleep, hydration and recovery.

Ep. 02 — NMN: the path to a better lifeJul 7, 2025

This episode zooms in on NMN alone: which scientifically backed effects are being researched, what supplement quality is all about (purity, dosage, independent certification), and how to use NMN in practice. Roald explains why not every NMN product is the same and gives practical usage advice for those starting for the first time — as part of a healthy lifestyle, not as a replacement for it.

Ep. 01 — The science behind NMN, NAD⁺, TMG and GlyNACApr 8, 2025

The very first episode lays the foundation: what is NAD⁺, why do NAD⁺ levels decline with age, and what role do NMN, TMG and GlyNAC play in that? NMN is converted into NAD⁺ in the body; TMG supports the methylation cycle; GlyNAC (glycine + N-acetylcysteine) contributes to the production of glutathione. Roald emphasizes that human research is still in its early stages and many results come from animal studies. A good introduction for those just starting out.

Frequently Asked Questions

What is the difference between NMN, TMG and GlyNAC?
NMN (nicotinamide mononucleotide) is a precursor to NAD⁺, a molecule involved in cellular energy. TMG (trimethylglycine) supports the methylation cycle in the body. GlyNAC is the combination of glycine and N-acetylcysteine and provides building blocks for glutathione, an important antioxidant. The three substances work through different mechanisms and are therefore often discussed together, not as replacements for one another.

Is NMN safe for daily use?
Research into the safety of NMN in humans is still limited, but so far no serious side effects have been reported at the dosages studied. Long-term research into years of daily use in humans is still lacking. In case of doubt, pregnancy, medication use or underlying conditions, always consult a physician first.

What is a common dosage of NMN?
In published human studies, dosages of approximately 250 to 900 mg of NMN per day have been investigated. The optimal dosage depends on factors such as age, health and goals, and is not yet a fixed scientific consensus figure. If in doubt, increase your intake gradually and follow the advice on the packaging.

Does NMN slow aging in humans?
No, that has not yet been demonstrated. Animal and cell studies show promising effects on NAD⁺ levels and cellular energy, but direct evidence that NMN slows aging in humans is currently lacking. The podcast consciously makes this distinction between preclinical research and proven effects in humans explicit.

Can you use NMN, TMG and GlyNAC together?
Yes, the three substances work through different pathways — NAD⁺ production, methylation, glutathione synthesis — and are therefore often discussed in combination. Whether combining them makes sense for you depends on your personal situation and goals. If in doubt, introduce one supplement at a time and monitor how your body reacts.

What should I look for when buying NMN supplements?
Look for purity and independent laboratory testing, a clear dosage per capsule, transparency regarding the raw material source, and a realistic product claim — distrust promises that sound like a miracle cure.