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Short answer: TMG (trimethylglycine, also called betaine) is a methyl group donor your body uses to convert homocysteine into methionine. Every Day Better sells TMG Capsules with 500 mg per capsule (60 vegan capsules, €21.50, or €0.36 per capsule) and an NMN + TMG bundle (€67.00). Free shipping within Europe on orders over €50.
| Product | Contents | Price | Per capsule / dose |
|---|---|---|---|
| TMG Capsules 60 x 500 mg | 60 vegan capsules (30 g TMG) | €21.50 | €0.36 per 500 mg |
| NMN + TMG bundle | 60 NMN capsules (250 mg) + 60 TMG capsules (500 mg) | €67.00 | €5.50 cheaper than buying separately |
Already taking NMN? Then the bundle is the most economical way to have both at home.
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NMN and TMG Bundle – 60 NMN capsules + 60 TMG capsules
€ 67,00 -
TMG Capsules 60x500mg – 60 vegan capsules
€ 21,50
What is TMG (trimethylglycine)?
TMG is the amino acid glycine with three methyl groups attached. It occurs naturally in beets (where the name betaine comes from), spinach, quinoa and wheat bran. Your body also makes it from choline. TMG donates its methyl groups to other molecules; this process is called methylation. Read the full explanation in our TMG guide.
What does TMG do in the body?
The best-known function of TMG is converting homocysteine into methionine, via the enzyme betaine-homocysteine methyltransferase (BHMT) in the liver and kidneys. A daily intake of 1.5 grams of betaine contributes to normal homocysteine metabolism; this relationship has been assessed by EFSA. Methionine in turn is the basis for SAMe, the main methyl donor for processes including DNA methylation and the production of neurotransmitters. Read more about the studies in TMG research and betaine and homocysteine.
Why TMG together with NMN?
When NAD⁺ is broken down, nicotinamide is released. The body clears it partly by attaching a methyl group to it (via the enzyme NNMT). Anyone taking NMN daily may therefore use up extra methyl groups. TMG is added to replenish them. This is a biochemical rationale; controlled studies of the NMN + TMG combination are still lacking. Read more about the NMN + TMG combination or browse our NMN supplements.
How much TMG per day?
| Situation | Common amount | 500 mg capsules |
|---|---|---|
| Alongside 250 to 500 mg NMN | 500 mg | 1 per day |
| Alongside 1,000 mg NMN or more | 1,000 mg | 2 per day |
| Homocysteine metabolism | 1,500 mg | 3 per day |
Higher doses (from around 4 grams per day) can cause digestive complaints and, in studies, slightly raise LDL cholesterol. See TMG dosage and TMG side effects.
TMG or betaine HCl?
TMG (betaine anhydrous) and betaine HCl are not the same. Betaine HCl is used as a source of stomach acid to aid digestion; TMG is the form used as a methyl group donor. The difference is explained in TMG vs betaine.
What to look for when buying TMG
- Form: TMG or betaine anhydrous, not betaine HCl.
- Amount per capsule and total grams per pack.
- Price per gram of TMG: with us €0.72 per gram (60 x 500 mg for €21.50).
- Capsule and additives: our capsules are made of plant-based HPMC and are free from GMOs, gluten and lactose.
Find more buying advice in buying TMG in the Netherlands.
Frequently asked questions about TMG
What is TMG?
TMG (trimethylglycine) or betaine is a compound with three methyl groups that the body uses to convert homocysteine into methionine. It is found in foods such as beets, spinach and quinoa.
Why do people take TMG with NMN?
When NAD⁺ is broken down, nicotinamide is methylated, which uses up methyl groups. TMG is a methyl group donor and is added to replenish them. Studies of the combination are still lacking.
How much TMG should you take per day?
Alongside NMN, most people take 500 to 1,000 mg of TMG per day (1 to 2 capsules). For normal homocysteine metabolism, 1,500 mg per day is the amount studied.
Is TMG the same as betaine?
TMG is betaine anhydrous. It is not the same as betaine HCl, which is used as a digestive aid.
Does TMG have side effects?
Rarely at common doses. From around 4 grams per day, digestive complaints and a slight rise in LDL cholesterol have been reported.
How long does a pack of TMG last?
60 days at 1 capsule per day, 30 days at 2 capsules per day.
Food supplements are not a substitute for a varied diet and a healthy lifestyle. Consult a doctor if you are pregnant, breastfeeding, taking medication or have medical complaints.
