New Scientific Measurement Method Proves Recording NMN More Accurate

A Revolution in Research and NMN Measurements In the world of aging and metabolism research, NMN has emerged as a crucial molecule.
As a key precursor in the biosynthesis of Nicotinamide Adenine Dinucleotide (NAD+), NMN plays an essential role in various biological processes, including aging, DNA repair and energy metabolism.
The ability to accurately measure levels is vital to understanding its impact on health, disease and healing.
Perhaps somewhat technical, but until now quantifying NMN in biological samples has been challenging.
Sensitivity to enzymatic degradation made accurate measurements difficult.
This has recently changed with the introduction of dual isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS), an innovative methodology that promises to change the landscape of NMN measurements. The Advancing Methodology: dimeLC-MS/MS dimeLC-MS/MS uses liquid chromatography-triple quadrupole mass spectrometry, but with a twist – it uses double isotopic NMN standards.
This approach significantly improves the accuracy of NMN measurements by adjusting for matrix effects inherent in biological samples.
This methodology has been extensively tested and has shown remarkable accuracy in quantifying NMN levels in mouse plasma.
Hereby, the rapid uptake of NMN into blood circulation and cells has also been proven. Implications For The Future The development of the dimeLC-MS/MS method is a mega-step in how to research NMN and its effects on animals and humans.
It potentially provides a reliable standard methodology that could reshape our understanding of aging, metabolism and perhaps even the broader field of biochemistry.
This progress is not just academic.
With more accurate measurements, researchers can better understand the effectiveness of NMN, optimize doses and unravel the complex interplay of NAD+ metabolism in health and disease.
We can’t wait to see how this will change the field!
Source: Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS)